abstract：:Vascular smooth muscle cell (VSMC) accumulation and endothelial cell dysfunction are associated with pathogenesis of atherosclerosis. Long noncoding RNA taurine up-regulated gene 1 (TUG1) has been reported to play an important role in cardiovascular diseases, including atherosclerosis. However, the regulatory mechanis...

journal_title：Life sciences

authors： Wu X,Zheng X,Cheng J,Zhang K,Ma C

更新日期：2020-02-15 00:00:00

abstract：AIMS:To investigate the therapeutic effects of human amniotic mesenchymal stem cells (hAMSCs) on paraquat (PQ)-induced pulmonary fibrosis in rats and investigate the inflammatory mechanisms. MAIN METHODS:hAMSCs were identified by morphological, flow cytometry and immunocytochemistry. A pulmonary fibrosis model was ind...

journal_title：Life sciences

authors： He F,Wang Y,Li Y,Yu L

更新日期：2020-02-15 00:00:00

abstract：AIMS:Circular RNAs (circRNAs) have been emerged as novel regulators in multiple tumorigenesis, including melanoma. CircRNA_0084043 was recently demonstrated to be deregulated in human melanoma cells. Nevertheless, its role and mechanism are largely unrevealed in melanoma. MATERIALS AND METHODS:Expression of circ_00840...

journal_title：Life sciences

authors： Chen Z,Chen J,Wa Q,He M,Wang X,Zhou J,Cen Y

更新日期：2020-02-15 00:00:00

abstract：AIM:Pancreatic stellate cells (PSCs) are the main functional cells leading to pancreatic fibrosis. Nicotine is widely considered as an independent risk factor of pancreatic fibrosis, but the mechanism is still unclear. Our study was aimed to explore the effects of nicotine on human pancreatic stellate cells (hPSCs) and...

journal_title：Life sciences

authors： Li Z,Zhang X,Jin T,Hao J

更新日期：2020-02-15 00:00:00

abstract：AIMS:Ovarian cancer (OC) is the most lethal gynecologic malignant tumors all over the world. HOX antisense intergenic RNA myeloid 1 (HOTAIRM1) has been reported as an important regulator in multiple tumors. However, the functions of HOTAIRM1 in OC and its possible molecular mechanisms remain unclear. MAIN METHODS:qRT-...

journal_title：Life sciences

authors： Chao H,Zhang M,Hou H,Zhang Z,Li N

更新日期：2020-02-15 00:00:00

abstract：:Autophagy is a metabolic process that maintains the homeostasis of the intracellular environment by degrading damaged proteins and organelles in lysosomes. Recently, independent studies have indicated that some hepatitis viruses develop abilities to hijack autophagy for their replication, such as hepatitis B (HBV) and...

journal_title：Life sciences

authors： Zhang L

更新日期：2020-02-01 00:00:00

abstract：AIMS:With the improvement of the survival rates in children acute lymphoblastic leukemia (ALL), some children ALL survivors show impaired cognitive function. Methotrexate (MTX), an essential component in ALL treatment, has been reported to be related to neurologic sequelae and to increased oxidative stress through its ...

journal_title：Life sciences

authors： Chen YC,Sheen JM,Hsu MH,Hsiao CC,Wang SC,Huang LT

更新日期：2020-02-01 00:00:00

abstract：AIMS:The present study was designed to compare the effects of a low-fat diet (LF), calorie restriction (CR), quercetin (Que) and exercise (Ex) on hepatic steatosis in a high-fat (HF) diet-induced obesity prone (OP) model in the perspective of microRNA (miR)-dependent thyroid hormone (TH) synthesis and action. MAIN MET...

journal_title：Life sciences

authors： Xia SF,Jiang YY,Qiu YY,Huang W,Wang J

更新日期：2020-02-01 00:00:00

abstract：:Ventricular hypertrophy is a risk factors for arrhythmias, ischemia and sudden death. It involves cellular modifications leading to a pathological remodeling and is associated with heart failure. The activation of the G protein-coupled estrogen receptor (GPER) mediates beneficial actions in the cardiovascular system. ...

journal_title：Life sciences

authors： Di Mattia RA,Mariángelo JIE,Blanco PG,Jaquenod De Giusti C,Portiansky EL,Mundiña-Weilenmann C,Aiello EA,Orlowski A

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND/AIMS:Previous studies have demonstrated that Galactooligosaccharides (GOS), known as "bifidus factor", has anti-inflammatory effects. Colitis, a kind of colonic inflammatory damage could be induced by different chemicals. The pathogenesis and mechanism of colitis remains unclear, and may be related to intest...

journal_title：Life sciences

authors： Chu H,Tao X,Sun Z,Hao W,Wei X

更新日期：2020-02-01 00:00:00

abstract：AIM:To investigate the cytotoxic effect of Peruvoside and mechanism of action in human cancers. MAIN METHODS:Cell viability was measured by MTT assay and the cell cycle arrest was identified by FACS. Real-time qPCR and western blotting studies were performed to identify important gene and protein expressions in the di...

journal_title：Life sciences

authors： Reddy D,Kumavath R,Tan TZ,Ampasala DR,Kumar AP

更新日期：2020-01-15 00:00:00

abstract：:Karyopherin α2 (KPNA2, also known as importinα-1), a member of the nuclear transporter family, is involved in the nucleocytoplasmic transport pathway of a variety of tumor-associated proteins. Recent studies have found that KPNA2 is overexpressed in various cancers, which is associated with poor prognosis. In addition...

journal_title：Life sciences

authors： Han Y,Wang X

更新日期：2020-01-15 00:00:00

abstract：PURPOSE:Doxorubicin, as an effective chemotherapeutic drug, is commonly used for combating various solid and hematological tumors. However, doxorubicin-induced cardiotoxicity is considered as a serious adverse effect, and it limits the clinical use of this chemotherapeutic drug. The use of melatonin can lead to a decre...

journal_title：Life sciences

authors： Najafi M,Hooshangi Shayesteh MR,Mortezaee K,Farhood B,Haghi-Aminjan H

更新日期：2020-01-15 00:00:00

abstract：AIMS:β-Adrenoceptors (β-ADRs) mediating the relaxation of rat superior mesenteric arteries (SMAs) were pharmacologically identified, and the effects of chemical sympathetic denervation on β-ADR-mediated relaxation were examined. MAIN METHODS:The tension changes of endothelium-denuded SMAs were isometrically recorded a...

journal_title：Life sciences

authors： Obara K,Shigematsu M,Takahasi H,Iiboshi Y,Yoshioka K,Kasuya Y,Tanaka Y

更新日期：2020-01-15 00:00:00

abstract：AIMS:LexA protein is a transcriptional repressor which regulates the expression of more than 60 genes belonging to the SOS global regulatory network activated by damages to bacterial DNA. Considering its role in bacteria, LexA represents a key target to counteract bacterial resistance: the possibility to modulate SOS r...

journal_title：Life sciences

authors： Bellio P,Mancini A,Di Pietro L,Cracchiolo S,Franceschini N,Reale S,de Angelis F,Perilli M,Amicosante G,Spyrakis F,Tondi D,Cendron L,Celenza G

更新日期：2020-01-15 00:00:00

abstract：:Immunotherapy with immune checkpoint inhibitors, such as anti-PD-1 drugs, is an area in increasing development for its efficacy and advantages in the treatment of advanced metastatic melanoma. In fact, immunotherapy has been the target of several and recent studies in different types of cancer, namely in melanoma, a g...

journal_title：Life sciences

authors： Moreira RS,Bicker J,Musicco F,Persichetti A,Pereira AMPT

更新日期：2020-01-01 00:00:00

abstract：:As soon as a pathogen invades through the physical barriers of its corresponding host, host mounts a series of protective immune response to get rid of the invading pathogen. Host's pattern recognition receptors (PRR), localized at the cellular surface, cytoplasm and also in the nucleus; recognises pathogen associated...

journal_title：Life sciences

authors： Rai RC

更新日期：2020-01-01 00:00:00

abstract：:C57BL6/J (B6) mice lacking Se-dependent GSH peroxidase 1 and 2 (GPx1/2-DKO) develop mild to moderate ileocolitis around weaning. These DKO mice have a disease resembling human very-early-onset inflammatory bowel disease (VEOIBD), which is associated with mutations in NADPH oxidase genes. Drugs including dexamethasone ...

journal_title：Life sciences

authors： Chu FF,Esworthy RS,Shen B,Gao Q,Doroshow JH

更新日期：2019-12-15 00:00:00

abstract：AIMS:The aims of the study are to investigate whether the combination of adipose-derived stem cells (ADSCs) with decellularized extracellular matrix (dECM) of myocardium can exert synergistic therapeutic effects on acute MI and the underlying mechanism. MAIN METHODS:Myocardial dECM from fresh porcine myocardium was pr...

journal_title：Life sciences

authors： Qiao L,Kong Y,Shi Y,Sun A,Ji R,Huang C,Li Y,Yang X

更新日期：2019-12-15 00:00:00

abstract：:Doxorubicin (DOX) induced cardiotoxicity is a life-threatening side effect of chemotherapy and decreased cardiac function can present years after treatment. Despite the investigation of a broad range of pharmacologic interventions, to date the only drug shown to reduce DOX-related cardiotoxicity in preclinical studies...

journal_title：Life sciences

authors： Zhen J,Yu H,Ji H,Cai L,Leng J,Keller BB

更新日期：2019-12-15 00:00:00

abstract：:Angiogenesis-targeted therapy of cancer is considered a promising strategy for therapeutic management of cancer progression. Over the last two decades, a few anti-angiogenesis monoclonal antibodies (mAbs) blocking VEGF signaling have been developed and approved by the FDA. The most widely used anti-angiogenesis drug i...

journal_title：Life sciences

authors： Fallah A,Heidari HR,Bradaran B,Sisakht MM,Zeinali S,Molavi O

更新日期：2019-12-15 00:00:00

abstract：:Colorectal cancer remains to be the most prevalent malignancy in humans and 1.5 million men and women living in the United States are diagnosed with colorectal cancer, with a predicted 145,600 new cases to be diagnosed in 2019. Curcuminoids and its synthetic analogs are now of interest due to their bioactive attribute...

journal_title：Life sciences

authors： Selvam C,Prabu SL,Jordan BC,Purushothaman Y,Umamaheswari A,Hosseini Zare MS,Thilagavathi R

更新日期：2019-12-15 00:00:00

abstract：OBJECTIVE:We aimed to explore the expression level and biological function of miR-145-5p in preeclampsia (PE). METHODS:The differentially expressed miRNA/mRNA between normal placentas and PE placentas were screened using the GSE84260 and GSE73374 datasets from the Gene Expression Omnibus Database. The expression of mi...

journal_title：Life sciences

authors： Lv Y,Lu X,Li C,Fan Y,Ji X,Long W,Meng L,Wu L,Wang L,Lv M,Ding H

更新日期：2019-12-15 00:00:00

abstract：AIMS:Enhanced aerobic glycolysis is an essential hallmark of malignant cancer. Blocking the glycolytic pathway has been suggested as a therapeutic strategy to impair the proliferation of tumor cells. Metformin, a widely used anti-diabetes drug, exhibits anti-tumor properties. However, the underlying molecular mechanism...

journal_title：Life sciences

authors： Hu,Zeng Z,Xia Q,Liu Z,Feng X,Chen J,Huang M,Chen L,Fang Z,Liu Q,Zeng H,Zhou X,Liu J

更新日期：2019-12-15 00:00:00

abstract：AIMS:Currently, chronic gastritis is a high incidence of digestive diseases, along with loss of appetite, abdominal pain and diarrhea. Baicalin belongs to the major bioactive flavonoids compounds from Scutellariae Radix, it exhibited anti-inflammatory and anti-bacteria activities. Nonetheless, the protective effects of...

journal_title：Life sciences

authors： Ji W,Liang K,An R,Wang X

更新日期：2019-12-15 00:00:00

abstract：AIMS:Benzodiazepines (BZDs) produce various pharmacological actions by binding to and allosterically regulating GABAA receptors. Several in vitro studies have demonstrated diazepam, the prototypic BZD, produces a high-dose action that cannot be countered with the classical BZD-binding site antagonist flumazenil. Here, ...

journal_title：Life sciences

authors： Cao Y,Yan H,Yu G,Su R

更新日期：2019-12-15 00:00:00

abstract：:Atherosclerosis (AS) is a chronic inflammatory disease that results from Oxidized low-density lipoprotein (Ox-LDL) induced endothelial dysfunction. Cytoplasmic polyadenylation element binding protein 1 (CPEB1) is closely related to the development of epithelial cells, but the role of CPEB1 in AS remains unknown. The R...

journal_title：Life sciences

authors： Xu K,Xiwen Liu,Ren G,Yin D,Guo S,Zhao Y

更新日期：2019-12-15 00:00:00

abstract：AIMS:In the cell, both transcriptional and translational processes are tightly regulated. Cancer is a multifactorial disease characterized by aberrant protein expression. Since epigenetic control mechanisms are also frequently disrupted during carcinogenesis, they have been the center of attention in cancer research wi...

journal_title：Life sciences

authors： Biterge-Sut B

更新日期：2019-12-01 00:00:00

abstract：:Cancer is a disease of high complexity. Resistance to therapy is a major challenge in cancer targeted therapies. Overcoming this resistance requires a deep knowledge of the cellular interactions within tumor. Natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) are the main anti-cancer immune cells, while T re...

journal_title：Life sciences

authors： Mortezaee K,Potes Y,Mirtavoos-Mahyari H,Motevaseli E,Shabeeb D,Musa AE,Najafi M,Farhood B

更新日期：2019-12-01 00:00:00

abstract：:LncRNA small nucleolar RNA host gene 3 (Snhg3) has been involved in cell proliferation and migration in malignant cells. However, its role in regulating functions of non-malignant cells has been hardly reported. Here, we found Snhg3 expression was sharply induced in primary brain microvascular endothelial cells (BMVEC...

journal_title：Life sciences

authors： Zhang J,Dong B,Hao J,Yi S,Cai W,Luo Z

更新日期：2019-11-15 00:00:00

abstract：AIMS:Stroke-prone spontaneously hypertensive rats (SHRSP) show significantly lower body weight than normotensive Wistar-Kyoto rats (WKY). Our hypotheses are as follows: weight loss of the skeletal muscle is related to hypertension-related diseases, and muscle hypotrophy is useful as a therapeutic target for hypertensio...

journal_title：Life sciences

authors： Inoue T,Hagiyama M,Maenishi O,Kimura M,Mizuguchi N,Mine Y,Kimura R,Chikugo T,Itoh T,Satou T,Ito A

更新日期：2019-11-15 00:00:00

abstract：:Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by symptoms that include social communication impairments, interaction deficits, and repetitive and stereotyped behaviors. Recent studies have suggested that imbalanced cytokine levels are associated with impaired behavioral outcomes in ind...

journal_title：Life sciences

authors： Ahmad SF,Nadeem A,Ansari MA,Bakheet SA,Alasmari F,Alasmari AF,Al-Kharashi LA,Al-Qahtani QH,Attia SM

更新日期：2019-11-15 00:00:00

abstract：AIMS:Long non-coding RNAs (LncRNAs) play central roles in the formation and development of gastric cancer (GC). The aim of this study was to evaluate the expression of PURPL and NONHSAT062994 and the relationship between their expressions with clinical characteristics in GC. MAIN METHODS:PURPL and NONHSAT062994 LncRNA...

journal_title：Life sciences

authors： Moridi H,Karimi J,Tavilani H,Khodadadi I,Emami Razavi AN

更新日期：2019-11-15 00:00:00

abstract：AIM:Over-expression of histone deacetylase 8 (HDAC8) has been demonstrated in breast cancer. But the underlying molecular mechanism of HDAC8 on the progression of breast cancer remains unknown. MicroRNAs (miRs) are proposed as important molecules in cancer progression by targeting specific oncogenes or tumor-suppressor...

journal_title：Life sciences

authors： Menbari MN,Rahimi K,Ahmadi A,Elyasi A,Darvishi N,Hosseini V,Mohammadi-Yeganeh S,Abdi M

更新日期：2019-11-15 00:00:00

abstract：OBJECTIVE:This study aims to evaluate the effective of azoles and MTX for patients with invasive candidiasis. METHODS:We used the disk diffusion assay and the checkerboard assay to evaluate the in vitro interactions between MTX and antifungals. In addition, we used the transmission electron microscopy to observe the u...

journal_title：Life sciences

authors： Yang J,Gao L,Yu P,Kosgey JC,Jia L,Fang Y,Xiong J,Zhang F

更新日期：2019-10-15 00:00:00

abstract：AIMS:To investigate the effects of malignant fibrous histiocytoma amplified sequence 1 (MFHAS1) on cognitive dysfunction, the expression of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β and amyloid β peptide (Aβ) in the hippocampus, as well as dendritic pathology in the hippocampal CA1 region in sepsis-associate...

journal_title：Life sciences

authors： Zhong J,Guo C,Hou W,Shen N,Miao C

更新日期：2019-10-15 00:00:00

abstract：:Substrate stiffness is essential for cell functions, but the mechanisms by which cell sense mechanical cues are still unclear. Here we show that the frequency and the amplitude of spontaneous Ca2+ oscillations were greater in chick cardiomyocytes cultured on the stiff substrates than that on the soft substrates. The s...

journal_title：Life sciences

authors： Liu S,Gao X,Wu X,Yu Y,Yu Z,Zhao S,Zhao H

更新日期：2019-10-15 00:00:00

abstract：AIMS:We performed a systematic review and meta-analysis on the effect of HIV infection and antiretroviral therapy (ART) on carotid intima-media thickness (cIMT) to elucidate the role of HIV infection and ART. Also, an analysis on the role of ethnicity and gender on cIMT in HIV-infected populations was performed. MAIN ...

journal_title：Life sciences

authors： Msoka TF,Van Guilder GP,van Furth M,Smulders Y,Meek SJ,Bartlett JA,Vissoci JRN,van Agtmael MA

更新日期：2019-10-15 00:00:00

abstract：:MicroRNAs plays important role in the development of myocardial infarction (MI). The aim of this study was to analyze whether miR-429 has effect on the process of autophagy in myocardial anoxia/reoxygenation (AR) or ischemia/reperfusion (IR) injury and explore the underlying mechanism. The results showed that miR-429 ...

journal_title：Life sciences

authors： Zhu Q,Hu F

更新日期：2019-10-15 00:00:00

abstract：:Sleep is crucial to improve athlete performance and their circadian rhythm, but sleep patterns may be disturbed because athletes participate in several competitions. In addition, intensive training programs can cause muscle pain and psychological stress in athletes, resulting in a lack of sleep. Sleep also plays a cri...

journal_title：Life sciences

authors： Yang DF,Shen YL,Wu C,Huang YS,Lee PY,Er NX,Huang WC,Tung YT

更新日期：2019-10-15 00:00:00